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KMID : 0620920190510070073
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Experimental & Molecular Medicine
2019 Volume.51 No. 7 p.73 ~ p.73
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Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction
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Zhang Lu
Li Fang
Su Xiaomin
Li Yue
Wang Yining
Fang Ruonan
Guo Yingying
Jin Tongzhu
Shan Huitong
Zhao Xiaoguang
Yang Rui
Shan Hongli
Liang Haihai
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Abstract
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Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring. Melatonin, a hormone produced by the pineal gland, plays an important role in multiple physiological and pathological responses in organisms. However, the function of melatonin in the development of bleomycin-induced pulmonary injury is poorly understood. In the present study, we found that melatonin significantly decreased mortality and restored the function of the alveolar epithelium in bleomycin-treated mice. However, pulmonary function mainly depends on type II alveolar epithelial cells (AECIIs) and is linked to mitochondrial integrity. We also found that melatonin reduced the production of reactive oxygen species (ROS) and prevented apoptosis and senescence in AECIIs. Luzindole, a nonselective melatonin receptor antagonist, blocked the protective action of melatonin. Interestingly, we found that the expression of apelin 13 was significantly downregulated in vitro and in vivo and that this downregulation was reversed by melatonin. Furthermore, ML221, an apelin inhibitor, disrupted the beneficial effects of melatonin on alveolar epithelial cells. Taken together, these results suggest that melatonin alleviates lung injury through regulating apelin 13 to improve mitochondrial dysfunction in the process of bleomycin-induced pulmonary injury.
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KEYWORD
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Diseases, Therapeutics
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